SMART DNA THERAPY

STRENGHTENING 4 SKIN BARRIERS
FOR #MYPERFECTSKIN EFFECT

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SMART DNA THERAPY

SMART DNA THERAPY is a multi-level antioxidant therapy with safety and efficacy confirmed in clinical studies supporting the protection and repair of cell DNA, providing an immediate radiant and rejuvenated appearance of the skin by acting on 4 skin barriers. The therapy is intended for all skin types, including hyper-reactive and sensitive skin.

SMART DNA THERAPY
MULTI LEVEL THERAPY FOR PERFECT SKIN EFFECT
  • Multi leve antioxidant therapy strenghtening 4 skin barriers

    • MICROBIOLOGICAL BARRIER – restoration of physiological self-regulation function, modulation of the microbiome1
    • CHEMICAL BARRIER - regeneration and reconstruction of the hydrolipid barrier2
    • PHYSICAL BARRIER – – strengthening of skin photoresistance and strong antioxidant action3 with protection and restoration of cell DNA4
    • IMMUNE BARRIER – anti-inflammaging1,2 action limiting premature skin aging caused by chronic inflammation
  • The concept of the treatment is based on a unique combination of ferulic acid, peptides and TGF-β2 growth factors. The synergy of active ingredients strengthens skin barriers, protects and repairs skin cells DNA, and thanks to the peptide content, neutralizes free radicals, reducing the signs of photoaging.
STRENGHTENING 4 SKIN BARRIERS FOR #MYPERFECTSKIN EFFECT
thanks to the multi-level synergy of active ingredients
EFFECTIVENESS AND SAFETY
CONFIRMED IN CLINICAL AND APPLICATION TESTS
MAIN INGREDIENTS
FERULIC ACID - protects the DNA of skin cells and repairs their damage caused by harmful external factors.

Reactions of active oxygen with sugar residues or nucleobases can lead to the formation of bonds between DNA strands, ultimately causing their breakage and cell death5. Ferulic acid triggers processes in fibroblasts that reduce the amount of reactive oxygen, thereby protecting the cell's DNA. It also reduces UV-induced cell cycle disruption and DNA damage by regulating gene expression6.

PEPTIDES - They express synergistic action with ferulic acid, including action against reactive forms of oxygen, sulfur, nitrogen and carbon.

PEPTIDE PROMOTER : ACETYL TETRAPEPTIDE-2 (V4S) - its synergy with ferulic acid has been demonstrated, among others, in action against reactive forms of oxygen, sulfur, nitrogen and carbon (ROS, RSS, RNS, RCS). Ultra-high antioxidant action compared to available forms of vitamin C was confirmed in the TEAC (Trolox Equivalent Antioxidant Capacity) study measuring the antioxidant capacity of the mixture of Ferulic Acid and Acetyl Tetrapeptide-2 with the standard - Trolox. High antioxidant power was also demonstrated in the spectrophotometric method showing the ability to neutralize the DPPH radical7.

HEKSAPEPTIDE ACETYL HEXAPEPTIDE-51 AMIDE increases gene expression, participates in processes such as cell proliferation and DNA repair. Activation of the DNA repair pathway imitating the action of FOXO3 by the hexapeptide was confirmed in the Host Cell Reactivation Assay study, conducted on epidermal keratinocytes. In vivo studies of the peptide also showed repair of DNA damage caused by UV radiation by significantly reducing the amount of pyrimidine dimers8.

TETRAPEPTIDE DIAMINOPROPIONOYL TRIPEPTIDE-33 supports the protection and repair of skin cell DNA. Protective activity was confirmed in both the Comet Assay and in vitro studies on human keratinocytes and fibroblasts exposed to a cytotoxic dose of sunlight. The peptide demonstrates the ability to repair DNA after direct irradiation of fibroblasts and inhibits the action of biomarkers of oxidative stress more effectively than carnosine9.

TGF-β2 GROWTH FACTOR - Stimulates the production of type I collagen – growth factor participates in the activation of the metabolic pathway leading to the production of type I collagen, without exhibiting photosensitizing properties.

AHA acids - (lactic, citric, malic) affect the skin keratinization process and the cohesion of corneocytes, thus slowing down the aging process10. Additionally, citric acid has a whitening effect and supports the action of antioxidants11.
SMART DNA
THERAPY
STRENGHTENING 4 SKIN BARRIERS
For perfect skin effect
2 STEP TREATMENT
WITH ANTIOXIDANT COMPLEX

STEP 1   SMART DNA AOX PEEL 40 ml
Advanced acid peeling with formula based on ferulic acid, a peptide promoter and TGF-ß2 growth factor with an identical metabolic pathway to retinoids for strong anti-aging stimulation and elimination of signs of exogenous aging.

STEP 2   SMART DNA MESO PEPTIDE COCKTAIL 2,5 ml
Sterile cocktail for microneedle mesotherapy, containing a mixture of peptides enhanced with ferulic acid, protects skin cells against DNA damage caused by exogenous and endogenous factors, neutralizes free radicals, thus reversing the signs of skin photoaging.
THE BOX CONTAINS:
SET OF 9 TREATMENTS
FOR PROFESSIONAL USE ONLY
HOME CARE


FERULIC TRIPPLE C SERUM
PROVEN ANTIOXIDANT EFFECTIVENESS12


Concentrated serum enriched with a complex of seven powerful antioxidants - AOX Cell Protect 7.0 prevents premature skin aging and smoothes fine wrinkles.
  • Provides optimal protection against harmful external factors and free radicals
  • Illuminates the skin and brightens discolorations
  • Smoothes fine wrinkles
  • Visibly rejuvenates the skin's appearance
FERULIC TRIPPLE C SPF CREAM
PROVEN PROTECTION AGAINST EXTERNAL FACTORS13


Antioxidant cream that protects against free radicals and UVA, UVB, HEV and IR radiation. Contains AOX Cell Protect 5.0 complex rich in 5 antioxidants. The combination of selected filters and strong antioxidants has a synergistic action preventing the effects of photoaging.
  • Provides optimal protection against harmful external factors, uv radiation and free radicals
  • Illuminates and brightens the skin
  • Stimulates collagen synthesis and reduces fine lines
  • Soothes and relieves
WHAT THE TREATMENT LOOKS LIKE?
TREATMENT PROTOCOL
20 - 28 days
IN THE OFFICE

The full therapy consists of a series of 3 SMART DNA THERAPY treatments performed every 10-14 days in combination with home care.

AT HOME

It is recommended to use FERULIC TRIPPLE C SERUM and FERULIC TRIPPLE C SPF CREAM all year round to maintain the effects of the treatment.

MULTI LEVEL ANTIOXIDANT THERAPY
detailed protocol
Step 1
APPLICATION OF SMART DNA AOX PEEL 2 layers 5 minutes apart (SANDWICH TECHNIQUE).
Maximum time - 10 minutes.

OPTION: gentle massage between applied layers of peeling. Peeling provides strong anti-aging stimulation, protects the DNA of skin cells and reduces visible signs of aging.
Step 2
APPLICATION OF SMART DNA MESO PEPTIDE COCKTAIL on the skin using the micro-needling procedure (forehead, cheeks, neck, décolleté).

Thanks to the content of ferulic acid, hyaluronic acid and peptides, the product protects the skin cells DNA from damage, regenerates and repairs the epidermis, leaving the skin moisturized, firm and full of radiance.

forehead
cheeks
neck, décolleté

  • Micro-needling of normal, combination, oily, mature skin:
    needle cartridges - depth of punctures 0.2-0.3 mm forehead and eye area, up to 0.5 mm cheeks, neck, décolleté
  • Nano-needling of vascular, sensitive skin:
    nano cartridges - depth of punctures 0.5-0.75 mm
FRACTIONAL MESOTHERAPY: controlled skin damage with microscopic needles

  • stimulates collagen, elastin production and the healing process
  • stimulates fibroblast activity
  • improves skin density and reduces acne scars, shallows fine wrinkles, smooths skin irregularities
  • increases the assimilation of active ingredients
  • improves skin tone and lightens discolourations by stimulating cell renewal and exfoliating the epidermis
EFFECTIVENESS OF SMART DNA THERAPY
IMMEDIATE ACTION
  • Brightening and visibly smoothing the complexion
  • Increased skin tension, firmness and elasticity
  • Reducing the visibility of superficial wrinkles
  • Rebuilding the hydrolipid barrier and improving the level of hydration
  • Narrowing of enlarged pores
ACTION AT THE CELLULAR LEVEL
  • Protection against free radicals and DNA repair in skin cells
  • Stimulation of regeneration without causing inflammation
  • Reducing skin reactivity
  • Alleviating inflammation and physiological reconstruction of the skin barrier
EFFECTIVENESS OF SMART DNA THERAPY
ACTION ON MICROBIOLOGICAL BARRIER1
See the results
POSITIVE INFLUENCE ON MICROBIOLOGICAL BARRIER1
Restoration of physiological self-regulation function, modulation of the microbiome by increasing the number of commensal bacteria and eliminating pathogens affects the promotion of antioxidants, which is key to maintaining skin health and youthful appearance.
  • increase in the number of Staphylococcus epidermidis, which supports the skin's antioxidant mechanisms
  • reduction of pathogens , that can cause inflammation and increase the production of ROS.
  • maintenance of a healthy microbiota, producing antimicrobial peptides that protect against infections and stimulating the development of regulatory T lymphocytes (Treg), which are key to preventing excessive inflammatory and autoimmune reactions.
FOREHEAD

Test shows increase in number of commensal bacteria and elimination of pathogens

FOREHEAD BEFORE TREATMENT | FOREHEAD AFTER TREATMENT

CHEEKS

Test shows increase in number of commensal bacteria and elimination of pathogens

CHEEK BEFORE TREATMENT | CHEEK AFTER TREATMENT

EFFECTIVENESS OF SMART DNA THERAPY
ACTION ON HYDROLIPID BARRIER2
See the results
POSITIVE INFLUENCE ON CHEMICAL BARRIER2
Regeneration and reconstruction of the hydrolipid barrier, influence the maintenance of firmness and elasticity as well as the appropriate level of hydration.
  • Improved skin hydration and reduced TEWL by up to 33%
  • Normalized skin pH by up to 17%
  • Regulated sebum secretion and reduced sebum density by up to 21%
  • Reduced superficial wrinkles, improved firmness and color
EFFECTIVENESS OF SMART DNA THERAPY
ACTION ON PHYSICAL BARRIER3,4
See the results
POSITIVE INFLUENCE ON PHYSICAL BARRIER3,4
Strengthening skin photoresistance and strong antioxidant action. A properly functioning physical barrier reduces the effects of the negative impact of UV radiation and protects against free radicals3, contributing to slowing down the skin photoaging process as well as protecting and repairing DNA of skin cells. 4
DNA PROTECTION:

The product has a protective action reducing the amount of skin cel DNA damage by 25%4



PROTECTIVE ACTION

The preparation was applied to the skin using a microneedle mesotherapy technique in accordance with the treatment procedure. The study showed that the product reduces the content of thymine dimers by 25%, the color of which in the histological phase of the study indicates damage to the DNA of cells.

DNA REPARATION:

The product increases the effectiveness of the DNA repair mechanisms of skin cells by 52%4



REPARATION ACTION

The preparation was applied to the skin using microneedle mesotherapy according to the treatment procedure. The results confirmed that the product increases the content of the UDG (Uracil-DNA Glycosylase) enzyme in the skin exposed to UV radiation by 52%.

EFFECTIVENESS OF SMART DNA THERAPY
ACTION ON IMMUNE BARRIER1,2
See the results
POSITIVE INFLUENCE ON IMMUNE BARRIER1,2
Anti-inflammaging action - limiting premature skin ageing caused by chronic inflammation, reducing skin reactivity and redness1,2.
  • Reduction of redness
  • Reduction of superficial wrinkles, improvement of firmness
  • Improvement of color

11. Open clinical trial, “The effect of SMART DNA Therapy Retix.C application on the skin microbiome” under the supervision of prof. PhD MD. Aleksandra Lesiak, report dated 09/06/2024; I 2.Open clinical trial, “The effect of SMART application on selected skin parameters” supervised by prof. PhD MD. Aleksandra Lesiak, n=20; I 3. Dr Koziej Institute of Cosmetics Research; Test report on evaluation of anti-radical activity of the product: peptide vial fbr26.06 en13213 cad:01/202 I 4. Laboratoire BIO EC France; Study 22E5550 Assessment of DNA protection and reparation activities of a product on human living skin explants ex vivo. I 5. A. Kamm, I. Załęska, „The use of ferulic acid in medicine and cosmetology”, Klinika Dermatologii, Wenerologii i Alergologii Gdańskiego Uniwersytetu Medycznego, Pol J Cosmetol 2017, 20(4), 276-287 I 6. H. J. Hahn, K. B. Kim, S. Bae, B. G. Choi, S. An, K. J. Ahn, S. Y. Kim, “Pretreatment of Ferulic Acid Protects human dermal fibroblasts against Ulytraviolet a Irridation”, Ann Dermatol, Vol. 28, No. 6, 2016 I 7. Manufacturer materials I 8. Manufacturer materials I 9. Manufacturer materials I 10. R. Jastrząd, M. Zabiszak, M. Nowak, "Fruit Acids (Alpha-Hydroxy Acids) and Their Complex Compounds", On the Border of Chemistry and Biology, Vol XXXIII, 2014 I 11. Bieniek A., Białynicki-Birula R., Barancewicz-Łosek M., Szepietowski J., Kuniewska B., Okulewicz-Gojlik DChemical Peels. Part I: Principle of Action, Historical Outline, Types of Peels, Complications, Dermatol Klin 2004, 6 (2): 109–114. I 12. Instrumental research – antioxidant effectiveness rate (DPPH) test; BIO-EC Laboratory; badanie 23E6128 I 13. Antioxidant capacity test, attachment nr BF/14/2023 to research report; GBA GROUP FOOD&ENVIRONMENT, COSMETICS